Clinical Papers for PRP

Comparison of Clinical Papers for PRP

The Arthrex Angel System is a revolutionary production system for platelet-rich plasma (PRP) formulations which can be exactly tailored to the specific treatment needs of the patient. Here is a summary of the clinical evidence showing efficacy.

“Characterisation and comparison of 5 Platelet-Rich Plasma Preparations in Single-Donor Model”

Magalon et al; 2014

Abstract: compare characteristics of Platelet-Rich Plasma (PRP) obtained from 4 commercially available systems(Selphyl, Regen PRP, Mini GPS III, Arthrex ACP).

Blood collected from 10 healthy donors; Volumes, platelets, Red and White Blood Cell concentrations were recorded; platelet activation was assessed, Growth Factor (GFs) concentrations were measured; platelet capture efficiency, platelet and GF doses, and composition for each system was determined.

Leukocyte-Rich PRP (LR-PRP) for Regen and Mini GPS III systems, Leukocyte-Poor PRP (LP-PRP) for AngelACP and Selphyl; centrifugation time did not affect platelet activation percentage; positive correlation between platelet dose and GFs present.

What to take away from this paper:

  • Many systems are available: must pick one that is suitable for desired application of PRP!
  • Angel system has real promise and is superior in main categories.
  • ACP is older system; the new Angel system is far better.

“Successful treatment of corticosteroid-resistant ophiasis-type Alopecia Areata with Platelet-Rich Plasma”

Donovan; 2016

Abstract: Alopecia Areata (AA) comes in many different forms; ophiasis affects back and sides of scalp and has been found to be more resistant to current treatments and technology; other kinds of AA, that have had more success from current treatments include monolocularis AA (in one area of the scalp) and multilocularis AA (“patchy” AA, over all of the scalp).

41-year-old woman, suffering from ophiasis-type AA and bipolar disorder; poor response to steroid treatments, with a systematic mood change after each treatment; previously treated with minoxidil and topical steroids, to no avail; suffered from patchy AA over the last decade, with an appearance of ophiasis-type AA over the last 2 years; blood test showed “normal” platelet count ( platelets).

What to take away from this paper:

  • PRP has real potential to treat steroid-resistant forms of AA.
  • Possibility to use PRP to counter the side effects of common treatments and can be very beneficial to certain patients.
  • Angel machine is a top choice for PRP manufacturing.

“Systematic review of Platelet-Rich Plasma use in Androgenetic Alopecia vs Minoxidil, Finasteride, Adult Stem-Cell Based Therapy”.

Gentile, Garcovich; 2020

Abstract: A big increase in Platelet Rich Plasma (PRP) studies for the treatment of Androgenetic Alopecia (AGA), with very successful results (84% showed positive results); most importantly, no major side effects

What to take away from this paper:

  • AA-PRP is a viable and suitable treatment for AGA.
  • Current treatments have obvious limitations, even when expanding horizon to stem cells.
  • Angel system and its benefits are briefly mentioned, its superiority highlighted.

“Evaluation of Not-Activated and Activated Platelet-Rich Plasma in Hair Loss Treatment: Role of Growth Factors and Cytokine Concentrations Obtained by Different Collection Systems”.

Gentile et al; 2017

Abstract: focus on Platelet-Rich Plasma (PRP) as potential therapy for Androgenetic Areata (AGA); split study with 2 different protocols:

first group (18 patients) treated with Autologous not-activated PRP (A-PRP); use CPunT System or Placebo; 3 treatments per patient at 30-day intervals.

second group (6 patients) treated with Autologous Activated PRP (AA-PRP); use Regen or Arthrex AngelSystem; singular set of injections, studied at 6 months.

What to take away from this paper

  • Both A-PRP and AA-PRP seem to be a viable option to treat AGA, with more success than current technology.
  • AA-PRP has advantage over A-PRP in terms of properties and outcome for patients.
  • Angel machine appears to produce higher quality PRP; richer in GFs, both in types and concentration.