“Evaluation of Not-Activated and Activated Platelet-Rich Plasma in Hair Loss Treatment: Role of Growth Factors and Cytokine Concentrations Obtained by Different Collection Systems”.
Gentile et al; 2017
Gentile et al; 2017
Abs: focus on Platelet-Rich Plasma (PRP) as potential therapy for Androgenetic Areata (AGA); split study with 2 different protocols:
Intro: AGA common hair loss disorder, affecting both men and women; also known as Male Pattern Hair Loss (MPHL) and Female Pattern Hair Loss (FPHL); MPHL leads to complete baldness; FPHL characterised by gradual thinning, rarely leads to complete baldness.
Possible treatments include:
A-PRP: improved surgical outcome and lower recurrence rate; release of Growth Factors (GFs) and cytokines dependant on body signalling.
AA-PRP: overall better efficiency when platelets activated as GFs and cytokines released immediately.
Compared by quantifying hair count, total hair density, epidermis thickness, follicle and hair cell count.
A-PRP: criteria compared 12 weeks after treatment to baseline values; increase of hair count and hair density, increase in epidermal thickness and hair cells number.
AA-PRP: criteria compared 6 months after treatment to baseline values; half received AA-PRP from Regen, half received AA-PRP from Angel; both showed increase in hair density and follicular unit density, with Angel group exhibiting superior results; increase in hair root and epidermal thickness, higher cell count, better vascularisation; Angel system had overall better results.
GFs were quantified and compared between the different groups and systems; lower concentration and types of GFs in A-PRP than AA-PRP; Angel product had overall superior GF concentration.
Discussion: platelet activation and protein release are natural consequence in body; activated by thrombin, release of α-granules that produce GFs; activated for many functional properties (clot formation, vascularisation, cell proliferation); positive effect on hair growth.
Epidermal thickness and vascularisation contribute to healthier and more favourable environment for hair cells to develop and grow; better oxygen and nutrients supply, more room to grow in.
What to take away from paper: