Autologous fat application is increasingly being used for breast and other reconstructive procedures as a ‘natural lipo filler’. Our fat is the body’s major source of mesenchymal stem cells, which are considered ‘multi-potent’ or ‘pluripotent’, as they have the ability to differentiate themselves into a number of different types of stem cells that are useful for wound healing, tissue repair and regeneration.
The expanding uses for a range of autologous biotherapies, is supported by the increasing body of clinical and scientific evidence of the synergistic effect of autologous fat and concentrated platelet rich plasma combinations, which is compelling both from a scientific perspective and from the clinical evidence.
Work by Zuk et al in the early 2000s provided us with insights of the potential of the adipose derived adult mesenchymal stem cells (AD-MSC) describing the importance of the progenitor cells within the stromal vascular fraction (SVF of harvested fat], working in conjunction with the extracellular matrix (ECM) and their overall synergistic effect on the viability of the autologous fat grafts.
‘Bio-active grafts’ for tissue regeneration
As pluripotent stem cells, adipose derived mesenchymal stem cells [AD-MSC] have the ability to dierntiate into a range of cell types, providing potential for aesthetic, reconstructive and regenerative medicine across a wide range of clinical applications.
Latest thinking suggests that the role of progenitor cells is even more important than previously acknowledged and that the long-term survival of AFG is directly linked to the activation and proliferation of these progenitor cells within the SVF, to differentiate into the target cells for replacement.
This intricate biological ballet occurs within a ‘cellular microenvironment of cell-to-cell/cell to matrix, and autocrine/paracrine signalling, and concentrated platelet rich plasma, rich in chemokines, cytokines and growth factors, considered to optimise the cellular microenvironment.
The convergence of science and technologies are providing a raft of therapies that are rapidly becoming mainstream in skin rejuvenation, tissue reconstruction and tissue regeneration.